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Year :2021
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Month :
March-April
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Volume :
10
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Issue :
2
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Page :
RO21 - RO23
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Magnetic Resonance Spectroscopy
Analysis of Normal Cerebral White
Matter at Different Regions
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Correspondence Address :
Penumalli Neelima, Vadana Bala Murali Krishna, Kanneganti Dharma Teja, K Chandra Sekhara Rao, BN Chander, Pyla Sudha Rani,
Dr. Vadana Bala Murali Krishna,
Dr. Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation,
Chinnaoutpalli, Gannavaram, Vijayawada-521286, Andhra Pradesh, India.
E-mail: sudharanipyla@gmail.com
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Introduction: Introduction: Conventional Magnetic Resonance Imaging (MRI) is a definitive method to check out structural and anatomical abnormalities of the brain, but it does not give any information regarding the functional or metabolic properties. Magnetic Resonance Spectroscopy (MRS) is widely used now-a-days for clinical applications and it also provides information about the metabolic properties of region of interest. The ideal way to analyse the magnetic resonance spectrum is to look at metabolite ratios such as NAA/Cr (N-Acetylaspartate and Creatine), Cho/Cr (Choline/Creatine) and NAA/Cho (N-Acetylaspartate/Choline).
Aim: To evaluate normal ratios of NAA/Cr, Cho/Cr and NAA/Cho in normal cerebral white matter in Indian population.
Materials and Methods: It was a prospective observational study carried out on 100 individuals with no history of trauma or known psychiatric illness who attended the Department of Radiodiagnosis in a period of two years from September 2010 to September 2012 in Dr. Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation, Chinnaoutpalli, Vijayawada, Andhra Pradesh, India. All data were collected, tabulated and statistically analysed using XLSTAT data analysis tool (Microsoft Excel) version 2010.
Results: The study was done in two cohorts. One includes study population of age range 20-35 years and other includes study population of age range 36-50 years. A total of 100 individuals were evaluated by performing MRS scan of which 65 were male (65%) and 35 were female (35%). The obtained ratios of NAA/Cr, Cho/Cr and NAA/Cho in 20-35 study age groups were 1.85, 0.81, 2.38, respectively. The obtained ratios of NAA/Cr, Cho/Cr and NAA/Cho in 36-50 study age group were 1.81, 0.84, 2.23, respectively.
Conclusion: The MRS is a non-invasive, radiation-free technique and is helpful to provide the metabolite information related to underlying dynamic physiology while being used as an adjuvant to MRI.
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