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Year :2022
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Month :
March-April
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Volume :
11
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Issue :
2
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Page :
RO23 - RO26
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Association of Severity of Non Alcoholic Fatty Liver Disease and Cardiometabolic Risk: A Cross-sectional Study
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Correspondence Address :
Ratna Vasanthan, Aishwarya Sreenivas, Krishna Kumar,
Aishwarya Sreenivas,
No. 9, First Cross Street (New Street), Vazhudavur Main Road, Gundupalayam, Puducherry-605009, India.
E-mail: draishwaryasreenivas@gmail.com
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Introduction: Introduction: Diagnosis of Nonalcoholic Fatty Liver Disease (NAFLD) and identifying its association with Metabolic Syndrome (MS) and other Cardiovascular (CV) risk factors will aid in early intervention and prompt treatment.
Aim: To determine the association of the severity of NAFLD defined by ultrasonography with the cardiometabolic profile of patients.
Materials and Methods: A cross-sectional study was conducted in the Department of Radiology, Sri Venkateshwaraa Medical College Hospital and Research Centre, Puducherry, India. The study was conducted in six months from January to June 2021. All the 100 patients diagnosed in the hospital with NAFLD, during the study period based on history and ultrasound imaging were included. Demographic data, co-morbidities, and data on metabolic profiles were collected. Grayscale B-mode transabdominal ultrasound imaging was used. The severity of NAFLD was assessed and graded by a blinded examiner. Oneway ANOVA test was used to compare the severity of NAFLD and metabolic profile. The p-value <0.05 was considered statistically significant. Data were analysed by using co-Guide software V.1.03.
Results: The mean age of the patients were 46.87 years. Majority (65%) were males. There was a statistically significant difference in Triglycerides (TG) (mg/dL) (p-value <0.001), Total Cholesterol (TC) (mg/dL) (p-value <0.001), HbA1c (p-value <0.05) and Alanine Transaminase (ALT) (p-value <0.034) among the patients across the groups graded according to severity of NAFLD.
Conclusion: An increase in metabolic parameters like TG, TC, HbA1c, and ALT were observed with the increase in the severity of NAFLD. The grading according to the severity of NAFLD will help in identifying the patients who are at increased CV risk.
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