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Year :2014
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Month :
September-October
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Volume :
3
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Issue :
3
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Page :
16 - 18
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High Grade Neuroendocrine Carcinoma
of The Gall Bladder: A Rare Entity
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Correspondence Address :
Channabasappa Kori, Sindhu V A, Sameer Gupta, Vijay Kumar, Kiran Preet Malhotra,
Dr. Vchannabasappa Kori
Senior Resident, Department of surgical oncology,
KGMC , Lucknow, India.
Phone : 9455061576
E-mail: Channabasappakori@gmail.com
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Introduction: Primary neuroendocrine carcinoma of the gall bladder (GB) is an extremely rare condition and is usually an incidental diagnosis. Here, we describe a rare case of primary gall bladder neuroendocrine carcinoma in a 30 year old lady who presented with upper abdominal pain and palpable lump in the right hypochondrium. Computed tomography of the abdomen showed an ill-defined heterogeneous soft tissue mass involving gall bladder and adjacent liver parenchyma with no obvious regional adenopathy. Metastatic work-up was normal and the patient underwent radical cholecystectomy. Histopathology and immunohistochemistry (IHC) study revealed high grade neuroendocrine carcinoma of the gall bladder involving the adjacent hepatic parenchyma. However, there was no evidence of clinical endocrinopathy. Patient received adjuvant chemotherapy and is disease free at 14 months of follow up. The present case emphasizes the need for better detection, evaluation and analysis of such rare entities, to identify their natural course and effective treatment modalities.
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