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Year :2017
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Month :
July-August
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Volume :
6
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Issue :
3
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Page :
RO68 - RO73
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A Study of Carotid Atherosclerosis in Subjects with non Alcoholic Fatty Liver Disease
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Correspondence Address :
Umamaheshwari Basavaraju, Manupratap Narayana, Vijay Prakash Kannan, Rajendrakumar
Narasipur Lingaiah, Nanjaraj Chakenahalli Puttaraj, Shashikumar Mysore Rangaswamy,
Pradeep Hagalahalli Nagarajegowda, Hemanth Purigali Naganna,
Dr. Manupratap Narayana,
127, Anikethana Road 2nd Cross South,
Kuvempunagara I Block,
Mysuru-570023, Karnataka, India.
E-mail: drmanupratap@gmail.com
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Introduction: Introduction: Non Alcoholic Fatty Liver Disease (NAFLD) is considered to be the hepatic manifestation of metabolic syndrome, a highly atherogenic condition. However, it is important to determine whether NAFLD is an independent predictor of cardiovascular disease.
Aim: To evaluate any possible association between NAFLD with Carotid Intima-Media Thickness (CIMT) and plaque prevalence, which are proven markers of subclinical atherosclerosis.
Materials and Methods: This cross-sectional study was conducted in the Department of Radiodiagnosis in Mysore Medical College. Total 200 patients between 18-60 years were subjected to abdominal sonography for assessment of presence or absence of fatty liver, followed by evaluation of both carotid arteries for CIMT and plaques. Statistical analysis was performed using Microsoft Excel 2013 and SPSS 20.0 software.
Results: Majority of subjects (64.5%) belonged to age group of 18 to 39 years. Total 121 female and 79 male subjects participated in the study. The prevalence of NAFLD in the study population was 31% among which 56% had Grade I fatty liver. The average maximum and mean CIMT in patients with NAFLD and non-NAFLD were 0.73 ± 0.16mm, 0.69 ± 0.14mm and 0.54 ± 0.14mm, 0.51 ± 0.13mm. The prevalence of plaques in normal population was 2.9% while that in NAFLD patients was 19.3%. Association between NAFLD and CIMT/plaques were statistically significant. As the grade of fatty liver increased the CIMT and incidence of plaques and hepatomegaly also increased.
Conclusion: NAFLD is a strong independent risk factor for atherosclerosis. Incidentally detected fatty liver on ultrasound should act as a trigger for complete cardiovascular risk assessment.
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