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Year :2018
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Month :
January-February
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Volume :
7
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Issue :
1
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Page :
NO01 - NO05
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Dexmedetomidine Versus Esmolol for Attenuation of Haemodynamic Response to Laryngoscopy and Tracheal Intubation in Hypertensive Patients
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Correspondence Address :
Kartik Syal, Bunty Sirkek, Gian Chauhan, Avinash Goyal,
Dr. Gian Chauhan,
Professor, Department of Anaesthesia,
Indira Gandhi Medical College, Shimla-171001,
Himachal Pradesh, India.
E-mail: gi.anjna@gmail.com
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Introduction: Introduction: Direct laryngoscopy and endotracheal intubation is noxious stimulus associated with marked haemodynamic response, mediated by polysynaptic sympathetic pathway. This response is transient, variable and unpredictable and may be detrimental in patients with systemic co-morbidities.
Aim: To compare effectiveness of dexmedetomidine (1 µg/Kg) vs. esmolol (1mg/Kg) for attenuating haemodynamic response in hypertensive patients (Grade I and II).
Materials and Methods: This prospective double blind interventional study was conducted on 80 hypertensive patients undergoing routine and emergency surgeries in Indira Gandhi Medical College and Hospital. Two sets of 10 mL syringes were prepared, coded A and B. Set A randomly contained Inj. dexmedetomidine or only normal saline; whereas set B randomly contained Inj. esmolol or only normal saline. Anaesthetists involved in patient management and recording of data were provided with both syringes A and B, to be given 10 minutes and 60 seconds before induction, respectively.
Result: Both dexmedetomidine and esmolol were effective in attenuation of haemodynamic response, dexmedetomidine consistently provided highly significant lower blood pressure values and heart rate throughout the study period, without any significant complications.
Conclusion: Both esmolol and dexmedetomidine was effective in blunting haemodynamic response to laryngoscopy and intubation.
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