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Year :2018
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Month :
September-October
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Volume :
7
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Issue :
4
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Page :
RO52 - RO57
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Comparison of Carotid Intima-Media Thickness in Patients With and Without Polycystic Ovarian Syndrome
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Correspondence Address :
Venkateshwaran Kallupalayam Natesan, Shivashankar Muthuswamyprabakaran, Akileshsuvindran, Senthilkumar Aiyappan,
Dr. Senthil Kumar Aiyappan,
Professor, Department of Radiology,
SRM Medical College Hospital and Research Centre,
Kattankulathur, Kancheepuram-603203,
Tamil Nadu, India.
E-mail: knvenkateshwaran@gmail.com
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Introduction: Introduction: Women with Polycystic Ovarian Syndrome (PCOS) have higher risk of obesity, hyperlipidemia, hyperinsulinemia and insulin resistance with progression to type 2 diabetes mellitus and hypertension which are risk factors for atherosclerosis. Carotid Intima-Media Thickness (CIMT) helps to identify the association of subclinical atherosclerosis with polycystic ovarian syndrome.
Aim: To assess the presence of subclinical atherosclerosis in young untreated women with PCOS by measuring the CIMT and comparing it with age matched controls.
Materials and Methods: A case control study was conducted in radiology department of SRM medical college and research centre on 70 women fulfilling the Rotterdam’s criteria for diagnosis of PCOS in the age group of puberty to 40 years and who underwent carotid Doppler and in which CIMT was measured. Seventy age matched normal women with regular menstrual cycle were enrolled as controls and their CIMT was measured. Statistical analysis was done using SPSS (IBM SPSS Statistics for Windows, Version 22.0, Armonk, NY: IBM Corp) was used. To compare the mean values between groups independent sample t-test was used and to compare proportions Chi-Square test/Fisher’s-exact test was used. Crude Odds Ratio was calculated to find the risk for Cases. Significance level was fixed as 5% (a=0.05).
Results: Intima media thickness in carotid arteries was increased in patients with PCOS compared to that of women without PCOS, suggesting that there is presence of subclinical atherosclerosis in young untreated women with PCOS. There was significant correlation between increased CIMT and PCOS patients (p-value <0.001). In the present study, there was also statistically significant increased body mass index in PCOS patients (p-value 0.002).
Conclusion: The higher sensitivity of CIM thickness measurements in detecting early atherosclerosis is an advantage for assessing the progression or regression of subclinical atherosclerotic disease over time and this can be successfully used in PCOS patients. Further studies are required with large sample size to substantiate the study results.
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