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Original article / research

2021
Year :2021 Month : January-February Volume : 10 Issue : 1 Page : RC01 - RC04

Langerhans Cell Histiocytosis with Temporal Bone Involvement- A Case Report

Published: January 1, 2021 | DOI: https://doi.org/10.7860/JCDR/2021/44569.2597
Correspondence Address :
Vishwanath Vijay Joshi, Neemish Kamat, Mitusha Verma, Ankur Gupta, Deepak Patkar,
Vishwanath Vijay Joshi,
Nanavati Superspeciality Hospital, Mumbai, Maharashtra, India.
E-mail: vishuvjoshi@gmail.com
Introduction: Langerhans Cell Histiocytosis (LCH) is a rare disorder of the reticuloendothelial system associated with proliferation of Langerhans cells and mature eosinophils. The hallmark of LCH is the proliferation and accumulation of a specific histiocyte: the Langerhan’s cell. Any organ or system can be affected. Here, a case of multisystem LCH with skeletal, lung and hepatobiliary involvement in a two-year child who presented with painless forehead swelling following trauma. The patient was systematically worked up with blood investigations, imaging and histopathological analysis which ultimately revealed the diagnosis of LCH. This case report is unique in that it presented with involvement of temporal bone wherein it can be confused with inflammatory pathologies like Cholesteatoma and tumours like Rhabdomyosarcoma. The child was started on vinblastine based chemotherapy and showed good response to therapy. This case report discusses the imaging differential diagnosis in temporal bone LCH along with utility of Positron Emission Tomography and Computed Tomography (PET-CT) in planning treatment of these cases.
 
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