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Year :2022
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Month :
September-October
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Volume :
11
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Issue :
4
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Page :
RC01 - RC02
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Cycloserine Induced Neurotoxicity: A Rare Case Report
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Correspondence Address :
Sarang Shishir Gosavi, Pranjali Prakash Patil,
Dr. Sarang Shishir Gosavi,
Ashvini Prasad Hospital, Station Road, Miraj, Maharashtra, India.
E-mail: saranggosavi14@gmail.com
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Introduction: Cycloserine is one of the many drugs used in treatment of Multidrug Resistant Tuberculosis (MDR-TB). Neuropsychiatric complaints are common after cycloserine administration. Reports of neuroimaging in cycloserine neurotoxicity are rare. Authors hereby reports a case of 17-year-old female, who presented with hallucination and delirium since 2 weeks. She was a known case of pulmonary MDR-TB and was on Anti-Koch’s Treatment category IV (AKT) for the same since last 12 months. On clinical examination, the patient was conscious and co-operative but disoriented. Magnetic Resonance Imaging (MRI) revealed, symmetric hyperintensities on T2 weighted images in bilateral dentate nuclei with restriction of diffusion, on diffusion weighted images. In addition, two well-defined T2 hypointense ring enhancing lesions were seen in right parietal and occipital regions. Patient’s symptoms improved on stoppage of cycloserine. On follow-up MRI, 4 weeks after withdrawing the drug, there was complete reversal of MRI findings.
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